Transcription profiling of E. coli cells during cell death programmed by a restriction-modification system

ABSTRACT: Genetically programmed deaths play important roles in the biology of unicellular prokaryotic cells. Some gene complexes force their maintenance on the host bacterial cells by killing cells that have lost them. This form of programmed death called post-segregational killing or genetic addiction is brought about by several Type II restriction-modification gene complexes, through restriction attack on the undermethylated chromosome, and underlie their behavior as selfish mobile elements. To learn the genetic steps to death, we examined how carriage and loss of PaeR7I restriction-modification gene complex affect host Escherichia coli cells through transcriptome and experimental analyses. The PaeR7I complex was on a temperature-sensitive plasmid so that the killing was induced by a temperature

ORGANISM(S): Escherichia coli

SUBMITTER: Yoko Asakura 

PROVIDER: E-GEOD-7326 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress