The effect of Heterogeneous Transcription Start Sites (TSS) on the Translatome: Implications for the Mammalian Cellular Phenotype.
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ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Joseph Curran
PROVIDER: E-GEOD-74232 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
The effect of heterogeneous Transcription Start Sites (TSS) on the translatome: implications for the mammalian cellular phenotype.
Dieudonné Francois-Xavier FX O'Connor Patrick B F PB Gubler-Jaquier Pascale P Yasrebi Haleh H Conne Beatrice B Nikolaev Sergey S Antonarakis Stylianos S Baranov Pavel V PV Curran Joseph J
BMC genomics 20151121
<h4>Background</h4>The genetic program, as manifested as the cellular phenotype, is in large part dictated by the cell's protein composition. Since characterisation of the proteome remains technically laborious it is attractive to define the genetic expression profile using the transcriptome. However, the transcriptional landscape is complex and it is unclear as to what extent it reflects the ribosome associated mRNA population (the translatome). This is particularly pertinent for genes using mu ...[more]
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