Transcriptional profiling of Coxiella burnetii reveals extensive cell wall remodeling in the small cell variant developmental form

ABSTRACT: A hallmark of Coxiella burnetii, the bacterial cause of human Q fever, is a biphasic developmental cycle that generates biologically, ultrastructurally, and compositionally distinct large cell variant (LCV) and small cell variant (SCV) forms. LCVs are replicating, exponential phase forms while SCVs are non-replicating, stationary phase forms. The SCV has several properties, such as a condensed nucleoid and an unusual cell envelope, suspected of conferring enhanced environmental stability. To identify genetic determinants of the LCV to SCV transition, we profiled the C. burnetii transcriptome by microarray at 3 (early LCV), 5 (late LCV), 7 (intermediate forms), 14 (early SCV) and 21 days (late SCV) post-infection (PI) of Vero epithelial cells. Relative to early LCV, genes down-regulated in

ORGANISM(S): Coxiella burnetii

SUBMITTER: Dan Sturdevant 

PROVIDER: E-GEOD-74489 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress