Transcription profiling of human peripheral blood mononuclear cells from healthy volunteers exposed to diesel exhaust inhalation

ABSTRACT: Background: Diesel exhaust (DE) is the primary source of urban fine particulate matter, which has been associated with cardiovascular disease in epidemiological studies. These effects may be related to oxidative stress and systemic inflammation with resulting perturbation of vascular homeostasis. Peripheral leukocytes are involved in both inflammation and control of vascular homeostasis. Objectives: We conducted an exploratory study using microarray techniques to analyze whether global gene expression in peripheral blood mononuclear cells (PBMCs) can inform on potential mechanisms of effect of DE inhalation. Methods: In a double-blind, crossover, controlled exposure study, healthy adult volunteers were exposed in randomized order to filtered air (FA) and diluted DE in two-hour sessions. W

ORGANISM(S): Homo sapiens

SUBMITTER: Richard Beyer 

PROVIDER: E-GEOD-7462 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress