The glucose-sensing transcription factor MLX promotes myogenesis via myokine signaling

ABSTRACT: Metabolic stress and changes in nutrient levels modulate many aspects of skeletal muscle function during aging and disease. Growth factors and cytokines secreted by skeletal muscle, known as myokines, are important signaling factors but it is largely unknown whether they modulate muscle growth and differentiation in response to nutrients. Here, we find that changes in glucose levels increase the activity of the glucose-responsive transcription factor MLX, which promotes and is necessary for myoblast fusion. MLX promotes myogenesis not via an adjustment of glucose metabolism but rather by inducing the expression of several myokines, including insulin like-growth factor-2 (IGF2), whereas RNAi and dominant-negative MLX reduce IGF2 expression and block myogenesis. This phenotype is rescued by

ORGANISM(S): Mus musculus

SUBMITTER: David Finkelstein 

PROVIDER: E-GEOD-74678 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress