Transcription profiling of mouse inflammatory response to titanium dioxide particles exposure is enhanced during pregnancy

ABSTRACT: Rationale: Maternal immune responses can promote allergy development in offspring. Pilot data show that neonates of mother mice exposed during pregnancy to air pollution particles have increased allergic susceptibility. Objective: We investigated whether inflammatory response to titanium dioxide (TiO2) particles earlier considered immunologically ‘inert’ is enhanced during pregnancy. Methods: Pregnant BALB/c mice (or non-pregnant controls) received particle suspensions intranasally at day 14 of pregnancy. Lung inflammatory responses were evaluated 19 and 48 h after exposure. Results: Pregnant mice showed robust and persistent acute inflammatory responses after exposure to TiO2, while non-pregnant females had the expected minimal responses. Genomic profiling identified genes differentia

ORGANISM(S): Mus musculus

SUBMITTER: Lester Kobzik 

PROVIDER: E-GEOD-7475 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress