Enhanced Phospholipase A2 group 3 expression by oxidative stress decreases the insulin-degrading enzyme

ABSTRACT: Oxidative stress has a ubiquitous role in neurodegenerative diseases and oxidative damage in specific regions of the brain is associated with selective neurodegeneration. We previously reported that Alzheimer disease (AD) model mice showed decreased insulin-degrading enzyme (IDE) levels in the cerebrum and accelerated phenotypic features of AD when crossbred with alpha-tocopherol transfer protein knockout (Ttpa-/-) mice. To further investigate the role of chronic oxidative stress in AD pathophysiology, we performed DNA microarray analysis using young and aged wild-type mice and aged Ttpa-/- mice. Among the genes whose expression changed dramatically was Phospholipase A2 group 3 (Pla2g3); Pla2g3 was identified because of its expression profile of cerebral specific up-regulation by chronic

ORGANISM(S): Mus musculus

SUBMITTER: Kaoru Mogushi 

PROVIDER: E-GEOD-75047 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress