Natural diversity in pentose fermentation is explained by variations in histone deacetylases

ABSTRACT: The extent to which carbon flux is directed towards fermentation vs. respiration differs between cell types and environmental conditions. Understanding the basic cellular processes governing carbon flux is challenged by the complexity of the metabolic and regulatory networks. To reveal the genetic basis for natural diversity in channeling carbon flux, we applied Quantitative Trait Loci analysis by phenotyping and genotyping hundreds of individual F2 segregants of budding yeast that differ in their capacity to ferment the pentose sugar xylulose. Causal alleles were mapped to the RXT3 and PHO23 genes, two components of the large Rpd3 histone deacetylation complex. We show that these allelic variants modulate the expression of SNF1/AMPK-dependent respiratory genes. Our results suggest that ov

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Zvi Tamari 

PROVIDER: E-GEOD-75673 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress