TE-associated chromatin variation in mice livers

ABSTRACT: Chromatin accessibility is a hallmark of active regulatory function in the genome and variation of chromatin accessibility across individuals has been shown to contribute to complex traits and disease susceptibility. However, the mechanisms responsible for chromatin variation among different individuals and how this variation contributes to phenotypic diversity remain poorly understood. We examined chromatin accessibility variation in liver tissue from seven strains of adult mice that have phenotypic diversity in response to a high-fat/high-sucrose diet. Remarkably, nearly 40% of the loci with the greatest degree of chromatin variability across the strains are associated with transposable elements (TEs), with evolutionarily younger TEs being particularly enriched for regions of chromatin v

ORGANISM(S): Mus musculus

SUBMITTER: Juan Du 

PROVIDER: E-GEOD-75770 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress