Evolution and genetic architecture of chromatin accessibility and function in yeast

ABSTRACT: Chromatin accessibility is an important functional genomics phenotype that influences transcription factor binding and gene expression. Genome-scale technologies allow chromatin accessibility to be mapped with high-resolution, facilitating detailed analyses into the genetic architecture and evolution of chromatin structure within and between species. We performed Formaldehyde-Assisted Isolation of Regulatory Elements sequencing (FAIRE-Seq) to map chromatin accessibility in two parental haploid yeast species, Saccharomyces cerevisiae and Saccharomyces paradoxus and their diploid hybrid. We show that although broad-scale characteristics of the chromatin landscape are well conserved between these species, accessibility is significantly different for 947 regions upstream of genes that are enri

ORGANISM(S): Saccharomyces cerevisiae x Saccharomyces paradoxus

SUBMITTER: Joshua Akey 

PROVIDER: E-GEOD-55717 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress