Molecular patterns of diffuse and nodular parathyroid hyperplasia in long-term hemodialysis

ABSTRACT: Secondary hyperparathyroidism is well known complication manifested in end-stage renal disease (ESRD). Both nodular and diffuse parathyreoid hyperplasia occur in ESRD patients. Distinct molecular mechanisms involved in parathyreoid hyperplasia remain poorly understood. Microarray screening proved homogeneity of gene transcripts in hemodialysis patients as compared to transplant cohort and primary hyperparathyreoidism, therefore further studies were performed in hemodialysis patints only. Enrichment analysis conducted on 485 differentially expressed genes between nodular and diffuse parathyreoid hyperplasia revealed highly significant differences in GO terms and KEGG database in ribosome structure (p=3.70-18). Next, RT-qPCR validation of microarray analysis proved higher expression of RAN g

ORGANISM(S): Homo sapiens

SUBMITTER: Petra Hruba 

PROVIDER: E-GEOD-75886 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress