The LIM homeodomain transcription factor Lhx2 is required for Müller glia development in the vertebrate retina.

ABSTRACT: Purpose: Müller glia are the only glial cell type produced by the neuroepithelial progenitor cells which generate the vertebrate retina. Müller glia are required to maintain retinal homeostasis and support the survival of retinal neurons. Furthermore, they function as an adult stem cell, mediating retinal regeneration among select vertebrate classes. However, the mechanisms which regulate Müller development are poorly understood as considerable overlap exists in gene expression between retinal progenitor cells and differentiated Müller glia. We investigate the functional role of the LIM homeodomain transcription factor Lhx2 in the specification and development of Müller glia in the mouse. Methods: RNA-Seq was performed in collaboration with the Johns Hopkins School of Medicine Dee

ORGANISM(S): Mus musculus

SUBMITTER: Seth Blackshaw 

PROVIDER: E-GEOD-75889 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress