BCL6 enforces human glioblastoma growth and serves as a novel therapeutic target (expression)

ABSTRACT: ZBTB transcription factors extensively orchestrate gene transcription during tissue development. However, their roles in glioblastoma multiforme (GBM) remain largely unexplored. Here, through integrated functional screening and expression analyses of 49 human ZBTB genes, we identify that BCL6 is required for GBM cell proliferation and is overexpressed in GBM samples. High expression of BCL6 is associated with poor overall survival of GBM patients. Genome-wide occupancy analysis and transcriptome analysis demonstrates that BCL6 is recruited to the loci of various tumor-promoting genes (e.g. MYC, FOSL1, MALAT1 and NEAT1) and maintains their expression. Pathway enrichment analysis reveals that BCL6 regulates several important cancer related pathways (e.g. TP53, ErbB and MAPK signaling pathway

ORGANISM(S): Homo sapiens

SUBMITTER: Phillip Koeffler 

PROVIDER: E-GEOD-77053 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress