Characterizing the transcriptional adaptation of Staphylococcus aureus to stationary phase growth

ABSTRACT: Staphylococcus aureus is an important human pathogen that causes life-threatening infections, and is resistant to the majority of our antibiotic arsenal. This resistance is complicated by the observation that most antibacterial agents target actively growing cells, thus, proving ineffective against slow growing populations, such as cells within a biofilm or in stationary phase. Recently, our group generated updated genome annotation files for S. aureus that not only include protein-coding genes but also regulatory and small RNAs. As such, these annotation files were used to perform a transcriptomic analysis in order to understand the metabolic and physiological changes that occur during transition from active growth to stationary phase; with a focus on sRNAs. We observed ∼24% of protein-

ORGANISM(S): Staphylococcus aureus

SUBMITTER: Andy Weiss 

PROVIDER: E-GEOD-77242 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress