Transcription profiling of human breast tumors to identify age-specific differences of oncogenic pathway deregulation

ABSTRACT: Breast cancer arising in young women has a poorer prognosis, is less likely to be hormone sensitive, and represents a particularly challenging clinical entity. The biology driving the aggressive nature of breast cancer arising in young women has yet to be defined. Among 784 patients with early stage breast cancer, using prospectively-defined, age-specific cohorts (young <= 45 years; older >= 65 years), 411 eligible patients (n = 200 < 45 years; n = 211 >= 65 years) with clinically-annotated Affymetrix microarray data were identified. Gene set enrichment analyses, signatures of oncogenic pathway deregulation and predictors of chemotherapy sensitivity were evaluated within the two age-defined cohorts. In comparing deregulation of oncogenic pathways between age groups, a statistically higher

ORGANISM(S): Homo sapiens

SUBMITTER: Carey Anders 

PROVIDER: E-GEOD-7849 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress