RNA-seq based transcriptome analysis of a highly virulent and multidrug resistant MRSA isolate for the understanding of virulence and resistance mechanisms

ABSTRACT: Staphylococcus aureus can infect a wide range of animals and pose as a serious threat to public health by transferring via animals or animal-derived food stuff. Even more importantly, multiple drug resistance development in the bacteria has resulted in therapeutic failure of a number of antibiotics. Therefore by realizing the need of time, this study was designed to investigate the underlying mechanisms of virulence and resistance in S. aureus. After screening through in vivo and in vitro virulence assays and susceptibility test, a highly virulent and multidrug resistant MRSA strain was selected for differential analysis by RNA-seq technology and gene expression results were verified by RT-qPCR. Up-regulation of crucial regulators like sarA and KdpDE seemed to play role in decreased expres

ORGANISM(S): Staphylococcus aureus

SUBMITTER: Hanqi Yin 

PROVIDER: E-GEOD-78764 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress