The Role of PTHrP in Osteoblast Response to Microgravity: Implications for Osteoporosis Development.

ABSTRACT: Prolonged skeletal unloading through bedrest results in bone loss similar to that observed in elderly osteoporotic patients, but with an accelerated timeframe. This rapid effect on weight-bearing bones is also observed in astronauts who lose up to 2% of their bone mass per month spent in Space. Despite important implications for Spaceflight travellers and bedridden patients on Earth, the exact mechanisms involved in disuse osteoporosis have not been elucidated. Parathyroid hormone-related protein (PTHrP) regulates many physiological processes including skeletal development, and has been proposed as a gravisensor. To investigate the role of PTHrP in microgravity-induced bone loss, trabecular osteoblasts (TOs) from Pthrp+/+ and -/- mice were exposed to simulated microgravity for 6 days.

ORGANISM(S): Mus musculus

SUBMITTER: Anne Camirand 

PROVIDER: E-GEOD-78980 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress