Transcription profiling of mouse functionally distinct radial glial subsets

ABSTRACT: Since the discovery of radial glia as the source of neurons, their heterogeneity in regard to neurogenesis has been described by clonal and time-lapse analysis in vitro. However, the molecular determinants specifying neurogenic radial glia differently from radial glia that mostly self-renew remain ill-defined. Here, we isolated two radial glial subsets that co-exist at mid-neurogenesis in the developing cerebral cortex and their immediate progeny. While one subset generates neurons directly, the other is largely non-neurogenic but also gives rise to Tbr2-positive basal precursors, thereby contributing indirectly to neurogenesis. Isolation of ; these distinct radial glia subtypes allowed determining interesting differences in their transcriptome. These transcriptomes were also strikingly di

ORGANISM(S): Mus musculus

SUBMITTER: Martin Irmler 

PROVIDER: E-GEOD-8034 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress