Affymetrix SNP array data of melanoma cell lines from lymph node metastates

ABSTRACT: Melanoma recurrence frequently occurs after a latency period of several years. In vivo studies demonstrated that tumor cells overcoming latency show a T cell-edited phenotype, suggesting a relevant role for CD8+ T cells in maintaining metastatic latency. Here, in a patient model of multiple recurrent lesions, we illustrate the genetic evolution of poorly immunogenic melanoma phenotypes, evolving in the presence of autologous tumor antigen-specific CD8+ T cells. Melanoma cells from two of three late recurrent metastases, developing within a 6-year latency period, lacked HLA class I expression. HLA class I-negative tumor cells became clinically apparent 1.5 and 6 years into stage IV disease. Genome profiling by SNP arrays revealed total T-cell resistance in both metastases originating from a

ORGANISM(S): Homo sapiens

SUBMITTER: Klaus Griewank 

PROVIDER: E-GEOD-80736 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress