Splicing towards noncoding isoforms in colorectal carcinoma is associated with tumor hypoxia and the DNA damage response

ABSTRACT: Tumor hypoxia is associated with poor patient outcome and resistance to therapy. It is associated with a rapid decline in protein production mediated through mTOR signalling. Here we show that it also leads to widespread changes in splicing and a global shift towards the expression of noncoding isoforms, thus providing a novel and orthogonal mechanism by which cells can modulate protein expression. Examination of mRNA levels in HCT116 cells after 0 hr, 1 hr, 2 hr and 24 hr in hypoxia. Three biological replicates each.

ORGANISM(S): Homo sapiens

SUBMITTER: Danish Memon 

PROVIDER: E-GEOD-81513 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress