Genes Differentially Expressed by Aspergillus flavus Strains After Loss of Aflatoxin Production by Serial Transfers

ABSTRACT: Aflatoxins are carcinogenic fungal secondary metabolites. Levels of aflatoxins in agricultural commodities are stringently regulated by many countries. A cluster of genes is responsible for aflatoxin biosynthesis by Aspergillus flavus and other closely related species. Expression of the clustered aflatoxin genes is governed by a complex network of regulatory mechanisms. To better understand the molecular events that are associated with aflatoxin production, transcription profiling by microarray analyses which compared three independent aflatoxigenic A. flavus strains to individual isogenic progenies that no longer produced aflatoxins after serial transfers was carried out. Twenty-two significantly differentially expressed features were identified. After physical mapping using the A. oryzae

ORGANISM(S): Aspergillus flavus

SUBMITTER: Jiujiang Yu 

PROVIDER: E-GEOD-8185 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress