The Role of CcpA in Gene Regulation in Streptococcus mutans

ABSTRACT: CcpA is a global regulator of transcription in Gram-positive bacteria that controls gene expression in response to carbohydrate availability. Using the fructan hydrolase (fruA) gene of S. mutans as a model, we demonstrate that CcpA does indeed play a major role in carbohydrate catabolite repression. Using DNA microarrays, the expression of at least 170 genes differed in CcpA-deficient cells compared to the parental strains when cells are grown in the presence of glucose, but only 90 genes showed altered expression when cells were cultivated in the poorly-repressing substrate galactose. Interestingly, 90 genes were differently expressed in wild-type S. mutans in response to cultivation in glucose versus galactose, but the expression of over 500 genes was altered when growth in glucose an

ORGANISM(S): Streptococcus mutans

SUBMITTER: Robert Burne 

PROVIDER: E-GEOD-8850 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress