Identification of markers associated with deregulated hTERT during HPV-medaited transformation

ABSTRACT: Although high-risk human papillomavirus (HPV) infection plays a major role in the development of cervical cancer, additive oncogenic events are involved as well. One key event involves increased activity of telomerase resulting from a deregulated expression of its catalytic subunit hTERT. Our previous microcell-mediated chromosome transfer studies revealed that introduction of human chromosome 6 in the HPV16 immortalized keratinocyte cell line FK16A and in the HPV16 containing cervical cancer cell line SiHa induced growth arrest, resulting from a repression of hTERT mRNA expression and telomerase activity. Here, this model was used to analyze expression profiles associated with hTERT deregulation in HPV transformed cells. Microarray expression analysis of 12 FK16A/chromosome 6 hybrids, fou

ORGANISM(S): Homo sapiens

SUBMITTER: Saskia Wilting 

PROVIDER: E-GEOD-8288 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress