Whole-transcript expression data from normal and DLBCL human peripheral blood samples
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Delphine Rossille
PROVIDER: E-GEOD-83632 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
T-cell defect in diffuse large B-cell lymphomas involves expansion of myeloid-derived suppressor cells.
Azzaoui Imane I Uhel Fabrice F Rossille Delphine D Pangault Celine C Dulong Joelle J Le Priol Jerome J Lamy Thierry T Houot Roch R Le Gouill Steven S Cartron Guillaume G Godmer Pascal P Bouabdallah Krimo K Milpied Noel N Damaj Gandhi G Tarte Karin K Fest Thierry T Roussel Mikael M
Blood 20160623 8
In diffuse large B-cell lymphoma (DLBCL), the number of circulating monocytes and neutrophils represents an independent prognostic factor. These cell subsets include monocytic and granulocytic myeloid-derived suppressor cells (M- and G-MDSCs) defined by their ability to suppress T-cell responses. MDSCs are a heterogeneous population described in inflammatory and infectious diseases and in numerous tumors including multiple myeloma, chronic lymphocytic leukemia, and DLBCL. However, their mechanis ...[more]
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