Defining memory-like CD8 T cells that respond to PD-1 therapy in chronic viral infection

ABSTRACT: Chronic viral infections are characterized by a state of CD8 T cell dysfunction termed exhaustion. A better understanding of the mechanisms that regulate CD8 T cell responses during chronic infection is required to improve immunotherapies that restore function in exhausted CD8 T cells. Here we identify a novel population of virus-specific CD8 T cells with a T follicular helper (Tfh)-like signature in mice chronically infected with lymphocytic choriomeningitis virus (LCMV). These Tfh-like CD8 T cells expressed the programmed cell death-1 (PD-1) inhibitory receptor but at the same time also expressed co-stimulatory molecules and had a gene signature that was related to CD8 T cell memory precursor cells and hematopoietic stem cells (HSC). These Tfh-like CD8 T cells acted as stem cells during

ORGANISM(S): Mus musculus

SUBMITTER: Haydn Kissick 

PROVIDER: E-GEOD-84105 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress