Transcription profiling of human patients with t(11;17) or t(7;17) translocations and with the RARA-PLZF status known were analysed for changes in expression related to the reciprocal status

ABSTRACT: This study supports an active role for PLZF and RARα-PLZF in leukemogenesis, identifies upregulation of CRABPI as a novel mechanism contributing to retinoid resistance and reveals the ability of the reciprocal fusion gene products to mediate distinct; epigenetic effects contributing to the leukemic phenotype. Experiment Overall Design: 5 patients with t(11;17) or t(7;17) translocations and with the RARA-PLZF status known were analysed for changes in expression related to the reciprocal status. This is a rare disease.

ORGANISM(S): Homo sapiens

SUBMITTER: Ken Mills 

PROVIDER: E-GEOD-8510 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress