Transcription profiling of mouse stratified epithelial spontaneous SCC induced by the somatic inactivation of Rb1 and Trp53 tumor suppressors

ABSTRACT: The squamous cell carcinomas represent the aggressive type of non melanoma skin cancer, the most frequent malignancy among human population. We have studied here the possible relationship between these two pathways in skin using epidermal-specific mutant mice. Loss of p53, but not pRb, produces spontaneous tumor development, indicating that, contrary to pRb, p53 is the predominant tumor suppressor acting in mouse epidermis. The simultaneous inactivation of pRb and p53 does not aggravate the epidermal phenotype observed in Rb-deficient mice in terms of proliferation and/or differentiation. However, in doubly deficient mice spontaneous skin tumor development is severely accelerated. The tumors are aggressive, undifferentiated and display a hair follicle origin. Detailed analysis indicates th

ORGANISM(S): Mus musculus

SUBMITTER: Ramón García-Escudero 

PROVIDER: E-GEOD-9144 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress