Transcription profiling of human childhood B-lineage ALL patients reveals five distinct biological processes and 14 differentially expressed genes characterize TEL/AML1-positive leukemia

ABSTRACT: Background; The t(12;21)(p13;q22) translocation is found in 20 to 25% of cases of childhood B-lineage acute lymphoblastic leukemia (B-ALL). This rearrangement results in the fusion of ETV6 (TEL) and RUNX1 (AML1) genes and defines a relatively uniform category, although only some patients suffer very late relapse. TEL/AML1-positive patients are thus an interesting subgroup to study, and such studies should elucidate the biological processes underlying TEL/AML1 pathogenesis. We report an analysis of gene expression in 60 children with B-lineage ALL using Agilent whole genome oligo-chips (44K-G4112A) and/or real time RT-PCR. Results; We compared the leukemia cell gene expression profiles of 16 TEL/AML1-positive ALL patients to those of 44 TEL/AML1-negative patients, whose blast cells did not

ORGANISM(S): Homo sapiens

SUBMITTER: virginie gandemer 

PROVIDER: E-GEOD-9170 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress