Transcription profiling of of human epididymal gene expression in the caput epididymides of infertile and fertile patients

ABSTRACT: Caput epididymides biopsies from 4 patients suffering from non-obstructive azoospermia and from 4 patients with active spermatogenesis were compared. 414 genes in the caput epididymides were differentially regulated in infertile men by at least a 2-fold change as compared to the fertile men. Experiment Overall Design: Comparative caput epididymal gene expression from 4 patients with either active spermatogenesis (reference samples) or non-obstructive azoospermia. On each array, infertile tissue were compared to fertile tissue. Whenever the fertile tissues were labeled with cyanine 5 (see samples entitled "Patients 1 and 2" and "Patients 7 and 8"), the fluorescence ratios were swapped. Data was normalized using a locally weighted regression Lowess method and genes were considered differenti

ORGANISM(S): Homo sapiens

SUBMITTER: Daniel Cyr 

PROVIDER: E-GEOD-9194 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress