Transcription profiling of rat low and high capacity - sedentary and trained: left ventricle

ABSTRACT: Aerobic capacity is a strong predictor of cardiovascular mortality. To determine the relationship between aerobic capacity and cardiac gene expression we examined genome-wide gene expression in hearts of rats artificially selected for high- and low running capacity (HCR and LCR, respectively) over 16 generations. HCR were born with an athletic phenotype, whereas LCR exhibited features of the metabolic syndrome. Left ventricle gene expression of both sedentary and exercise trained HCR and LCR was characterized by microarray- and gene ontology analysis. Western immunoblots and immunohistochemistry were used to validate the results at protein level. Out of 28.0000 screened genes, 1540 were differentially expressed between HCR and LCR. HCR expressed higher amounts of genes involved in lipid m

ORGANISM(S): Rattus norvegicus

SUBMITTER: Anja Bye 

PROVIDER: E-GEOD-9445 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress