Transcription profiling of mouse dendritic cells of cystic fibrosis animals without or with Pseudosmonas aeruginosa infection vs wild type dendritic cell controls

ABSTRACT: Dysfunction of the cystic fibrosis transmembrane regulator (CFTR) in cystic fibrosis (CF) results in exaggerated and chronic inflammation as well as increased susceptibility to chronic pulmonary infections, in particular with Pseudomonas aeruginosa. Based on the concept that host immune responses do not seem to be adequate to eradicate P.aeruginosa from the lungs of CF patients and that dendritic cells (DC) play an important role in initiating and shaping adaptive immune responses, this study analyzed the role of CFTR in bone marrow-derived murine DC from CFTR knockout (CF) mice with and without exposure to P.aeruginosa. DC expressed CFTR mRNA and protein, although at much lower levels compared to whole lung. Microarray analysis of gene expression levels in DC generated from CF and wild ty

ORGANISM(S): Mus musculus

SUBMITTER: Stefan Worgall 

PROVIDER: E-GEOD-9488 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress