Transcription profiling of mouse liver regeneration in Socs3 h-KO mice, Socs3 fl/fl, Alb-Cre- littermates controls

ABSTRACT: Suppressor of cytokine signaling 3 (SOCS3) down-regulates several signaling pathways in multiple cell types, and previous data suggest that SOCS3 may shut off cytokine activation at the early stages of liver regeneration. We developed hepatocyte-specific Socs3 knockout (Socs3 h-KO) mice to directly study the role of SOCS3 during liver regeneration after 2/3 partial hepatectomy (PH). Socs3 h-KO mice demonstrate marked enhancement of DNA replication and liver weight restoration after 2/3 PH in comparison with littermate controls. Without SOCS3, signal transducer and activator of transcription 3 (STAT3) phosphorylation is prolonged, and activation of the mitogenic kinases extracellular signal-regulated kinase 1/2 (ERK1/2) is enhanced after PH. In vitro, we show that SOCS3 deficiency enhances

ORGANISM(S): Mus musculus

SUBMITTER: Richard Beyer 

PROVIDER: E-GEOD-9549 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress