Mapping the Genetic Architecture of Gene Expression in Human Liver

ABSTRACT: To uncover the genetic determinants affecting expression in a metabolically active tissue relevant to the study of obesity, diabetes, atherosclerosis, and other common human diseases, we profiled 427 human liver samples on a comprehensive gene expression microarray targeting greater than 40,000 transcripts and genotyped DNA from each of these samples at greater than 1,000,000 SNPs. The relatively large sample size of this study and the large number of SNPs genotyped provided the means to assess the relationship between genetic variants and gene expression and it provided this look for the first time in a non-blood derived, metabolically active tissue. A comprehensive analysis of the liver gene expression traits revealed that thousands of these traits are under the control of well define

ORGANISM(S): Homo sapiens

SUBMITTER: eric schadt 

PROVIDER: E-GEOD-9588 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress