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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Identification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE9603: Identification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors on NIA 15k microarray GSE9619: Identification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors on NeuroDev microarray Keywords: SuperSeries Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: StÃ©phane LE CROM

PROVIDER: E-GEOD-9620 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors.

Pla Patrick P Hirsch Marie-Rose MR Le Crom Stéphane S Reiprich Simone S Harley Vincent R VR Goridis Christo C

Neural development 20080619

<h4>Background</h4>Branchiomotor neurons comprise an important class of cranial motor neurons that innervate the branchial-arch-derived muscles of the face, jaw and neck. They arise in the ventralmost progenitor domain of the rhombencephalon characterized by expression of the homeodomain transcription factors Nkx2.2 and Phox2b. Phox2b in particular plays a key role in the specification of branchiomotor neurons. In its absence, generic neuronal differentiation is defective in the progenitor domai ...[more]

PMID: 18565209

Similar Datasets

Identification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors on NIA 15k microarray

Project description:Branchiomotor neurons are an important class of cranial motor neurons that innervate the branchial-arch-derived muscles of the face, jaw and neck. They arise in the ventralmost progenitor domain of the rhombencephalon characterized by expression of the homeodomain transcription factors Nkx2.2 and Phox2b. Phox2b in particular plays a key role in the specification of branchiomotor neurons. In its absence, generic neuronal differentiation is defective in the progenitor domain, and no branchiomotor neurons are produced. Conversely, ectopic expression of Phox2b in spinal regions of the neural tube promotes cell cycle exit and neuronal differentiation and at the same time induces genes and an axonal phenotype characteristic for branchiomotor neurons. How Phox2b exerts its pleiotropic functions, both as a proneural gene and a neuronal subtype determinant, has remained unknown. To gain further insight into the genetic programme downstream of Phox2b we searched for novel Phox2b-regulated genes by cDNA microarray (here NIA 15k slides) analysis of facial branchiomotor neuron precursors from heterozygous and homozygous Phox2b mutant embryos. Keywords: Phox2b-regulated genes identification Four biological replicates each in dye swap

2010-05-25 | E-GEOD-9603 | biostudies-arrayexpress

Identification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors on NeuroDev microarray

Project description:Branchiomotor neurons are an important class of cranial motor neurons that innervate the branchial-arch-derived muscles of the face, jaw and neck. They arise in the ventralmost progenitor domain of the rhombencephalon characterized by expression of the homeodomain transcription factors Nkx2.2 and Phox2b. Phox2b in particular plays a key role in the specification of branchiomotor neurons. In its absence, generic neuronal differentiation is defective in the progenitor domain, and no branchiomotor neurons are produced. Conversely, ectopic expression of Phox2b in spinal regions of the neural tube promotes cell cycle exit and neuronal differentiation and at the same time induces genes and an axonal phenotype characteristic for branchiomotor neurons. How Phox2b exerts its pleiotropic functions, both as a proneural gene and a neuronal subtype determinant, has remained unknown. To gain further insight into the genetic programme downstream of Phox2b we searched for novel Phox2b-regulated genes by cDNA microarray (here NeuroDev slides) analysis of facial branchiomotor neuron precursors from heterozygous and homozygous Phox2b mutant embryos. Keywords: Phox2b-regulated genes identification Four biological replicates each in dye swap

2010-05-25 | E-GEOD-9619 | biostudies-arrayexpress

Looking for mitochondrial associated RNA

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2011-01-15 | E-GEOD-17366 | biostudies-arrayexpress

Silicon metabolism in diatoms

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2009-09-29 | E-GEOD-12015 | biostudies-arrayexpress

Role of the AMP deaminase Amd1p in purines interconversion in Saccharomyces cerevisiae

Project description:In this work, we show that under specific conditions, defect in AMP deaminase activity strongly impairs yeast cell growth and we establish that AMP deaminase is required for correct balance between adenylic and guanylic nucleotides. Study of the Amd1p homologs, Yjl070p and Ybr284p, reveals that overexpression of these proteins cannot suppress phenotypes associated to /amd1/ deletion but instead mimic in a wild-type strain a loss of Amd1p function. Data presented combined global transcription analyses to measurements of intracellular nucleotides pools by HPLC. Keywords: yeast strains implied in purines interconversion. 4 biological samples in dye-swap.

2010-06-20 | E-GEOD-9557 | biostudies-arrayexpress

Effect of adk1 knock-out mutation on global transcription

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2008-04-17 | E-GEOD-9553 | biostudies-arrayexpress

Effect of 5-amino-4-imidazolecarboxamide ribotide (AICAr) supplementation on global transcription

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2011-08-31 | E-GEOD-29019 | biostudies-arrayexpress

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Project description:We investigated the effects of the ploidy on cellular response in strains carrying various types of gross chromosomal rearrangements. Fourteen mutated strains (6 haploid strains and 8 diploid strains) were compared to their associated parental strain (haploid or diploid parental strain). For each comparison, 2 microarray experiments implying biological replicates were performed.

2011-06-17 | E-GEOD-28285 | biostudies-arrayexpress

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