Genotyping of human glioma - assessing the significance of chromosomal aberrations in cancer

ABSTRACT: Comprehensive knowledge of the genomic alterations that underlie cancer is a critical foundation for diagnostics, prognostics and targeted therapeutics. Systematic efforts to analyze cancer genomes are underway, but the analysis is hampered by the lack of a statistical framework to distinguish meaningful events from random background aberrations. Here, we describe a systematic method called Genomic Identification of Significant Targets in Cancer (GISTIC) designed for analyzing chromosomal aberrations in cancer. We use it to study chromosomal aberrations in 141 gliomas and compare the results with two prior studies. Traditional methods highlight hundreds of altered regions with little concordance between studies. The new approach reveals a highly concordant picture involving ~35 significan

ORGANISM(S): Homo sapiens

SUBMITTER: Rameen Beroukhim 

PROVIDER: E-GEOD-9635 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress