Candidate driver genes in focal chromosomal aberrations of stage II colon cancer

ABSTRACT: Chromosomal instable colorectal cancer is marked by specific large chromosomal copy number aberrations. Recently, focal aberrations of 3Mb or smaller have been identified as a common phenomenon in cancer. Inherent to their limited size, these aberrations harbour one or few genes. The aim of this study is to identify recurrent focal chromosomal aberrations and their candidate driver genes in a well defined series of stage II colon cancers and assess their potential clinical relevance. High resolution DNA copy number profiles were obtained from 38 formalin fixed paraffin embedded colon cancer samples with matched normal mucosa as a reference using array comparative genomic hybridization. In total, 81 focal chromosomal aberrations were identified that harboured 177 genes. Statistical validat

ORGANISM(S): Homo sapiens

SUBMITTER: Serge Smeets 

PROVIDER: E-GEOD-17047 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress