Comparative genomic hybridizarion of human osteosarcoma samples to determine genomic signatures of chromosomal instability and osteosarcoma progression detected by high resolution array CGH and interphase FISH

ABSTRACT: Background: Osteosarcoma (OS) tumors and derived cell lines are characterized by complex chromosomal abnormalities. The availability of molecular genome profiling techniques such as array CGH have markedly enabled the high-resolution genome analysis of tumor genomes, as well as helped elucidate the mechanisms leading to their complexity. The identification of tumor-specific genomic profiles is currently the focus of many array CGH studies, but there have been no analyses to date documenting the genomic signatures consistent with chromosomal instability mechanisms in OS. Results: In this study we utilized high-resolution oligonucleotide array CGH to interrogate recurrent signatures of genomic imbalance in 10 OS tumors that were consistent with the breakage fusion bridge(BFB) mechanis

ORGANISM(S): Homo sapiens

SUBMITTER: Shamini Selvarajah 

PROVIDER: E-GEOD-9654 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress