Transcription profiling of mouse skin after acute withdrawal of TERT

ABSTRACT: TERT is an essential protein component of telomerase, a ribonuclearprotein complex that protects chromosomal ends. Ectopic expression of TERT in mouse skin activates hair follicle stem cells and induces active growth phase of hair cycles, called anagen. This activity of TERT is independent of its reverse transcriptase function, indicating that this is a non-telomeric function of TERT. We performed time-course microarray analysis using conditional bi-transgenic mice (iK5-TERT) to understand the mechanism of this novel non-telomeric function of TERT. Experiment Overall Design: Hair follicles of iK5-TERT mice at postnatal day 60 is in TERT-induced anagen. To those mice, we injected either PBS, to maintain TERT transgene expression, or doxycycline, to rapidly extinguish transgene expression. W

ORGANISM(S): Mus musculus

SUBMITTER: Jinkuk Choi 

PROVIDER: E-GEOD-9725 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress