Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Rita Humeniuk
PROVIDER: E-GEOD-9764 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Mishra Pravin J PJ Mishra Prasun J PJ Humeniuk Rita R Medina Daniel J DJ Alexe Gabriela G Mesirov Jill P JP Ganesan Sridhar S Glod John W JW Banerjee Debabrata D
Cancer research 20080601 11
Carcinoma-associated fibroblasts (CAF) have recently been implicated in important aspects of epithelial solid tumor biology, such as neoplastic progression, tumor growth, angiogenesis, and metastasis. However, neither the source of CAFs nor the differences between CAFs and fibroblasts from nonneoplastic tissue have been well defined. In this study, we show that human bone marrow-derived mesenchymal stem cells (hMSCs) exposed to tumor-conditioned medium (TCM) over a prolonged period of time assum ...[more]