Human mesangial cell serum-treated for 6 h

ABSTRACT: Mesangial cells (MC) respond to various insults, such as hyperglycemia, with expressive phenotypic changes. Modifications in the patterns of MC proliferation, death, and the balance between matrix production and degradation affect directly glomerular function and ultimately lead to glomerulosclerosis. MC activation by growth factors (GF) has been demonstrated to be a trigger to changes in cell phenotype, and blockade of specific systems tend to attenuate glomerular damage. The identification of elements activated following GF stimulation of MC may facilitate the comprehension of the pathophysiology of glomerular diseases. By means of DNA microarray technology we identified that three inhibitors of DNA binding (ID1, ID3, and ID4) were among the most significantly regulated genes in serum-tr

ORGANISM(S): Homo sapiens

SUBMITTER: Thiago Maciel 

PROVIDER: E-GEOD-9787 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress