Transcription profiling of rat brain response to baculoviral vector transduction

ABSTRACT: Recombinant baculoviral vectors efficiently transduce several types of cells in the brain. To characterize host responses to viral challenge, thus verifying the suitability of using the virus for the development of gene therapy strategies in the central nervous system, we used cDNA microarray technology to examine in vitro and in vivo global cellular gene expression profiles after viral transduction. We demonstrated that the transduction induced host antiviral responses as a major reaction in all three types of samples profiled, including the rat brain, cultured human astrocytes and human neuronal cells. The related genes were mainly those associated with innate immunity. Several genes of the major histocompatibility complex molecules, an important component of the host adaptive immunity t

ORGANISM(S): Rattus norvegicus

SUBMITTER: Jerome Boulaire 

PROVIDER: E-GEOD-9833 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress