Transcription profiling of rodent hippocampal CA1 tissue during aging and cognitive decline

ABSTRACT: Recent microarray studies in the hippocampus of rodents or Alzheimer’s disease (AD) subjects have identified a substantial number of cellular pathways/processes correlated with aging and cognitive decline. However, the temporal relationships among these expression changes or with cognitive impairment have not been studied in depth. Here, using Affymetrix microarrays, immunohistochemistry and Morris water maze cognitive testing across 5 age groups of male F344 rats (n=9-15/group, one microarray per animal), we systematically analyzed the temporal sequence and cellular localization of aging changes in expression. These were correlated with performance scores on the hippocampus-dependent Morris Water Maze task. Significant microarray results were sorted in to Early, Intermediate, Midlife,

ORGANISM(S): Rattus norvegicus

SUBMITTER: Eric Blalock 

PROVIDER: E-GEOD-9990 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress