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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of excisional biopsy wounds from young and old human subjects to measure the influence of age on cutaneous wound healing

ABSTRACT: The aim of this experiment was measure the influence of age on cutaneous wound healing using human subjects. Increaded age has been associated with delayed wound healing in mouse models and in humans. Gene expression was compared between excisional biopsy wounds from young and old subjects.

ORGANISM(S): Homo sapiens

SUBMITTER: Leo Zeef

PROVIDER: E-MEXP-1074 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Estrogen, not intrinsic aging, is the major regulator of delayed human wound healing in the elderly.

Hardman Matthew J MJ Ashcroft Gillian S GS

Genome biology 20080513 5

<h4>Background</h4>Multiple processes have been implicated in age-related delayed healing, including altered gene expression, intrinsic cellular changes, and changes in extracellular milieu (including hormones). To date, little attempt has been made to assess the relative contribution of each of these processes to a human aging phenomenon. The objective of this study is to determine the contribution of estrogen versus aging in age-associated delayed human wound healing.<h4>Results</h4>Using an A ...[more]

PMID: 18477406

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