Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling by array of human T24 bladder cancer cells in response to hypericin-mediated photodynamic therapy in the absence or presence of the p38 MAPK inhibitor PD169316

ABSTRACT: Study of the gene expression of T24 bladder cancer cells in response to hypericin-mediated photodynamic therapy in the absence or presence of the p38 MAPK inhibitor PD169316

ORGANISM(S): Homo sapiens

SUBMITTER: pierre close

PROVIDER: E-MEXP-1220 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Molecular effectors and modulators of hypericin-mediated cell death in bladder cancer cells.

Buytaert E E Matroule J Y JY Durinck S S Close P P Kocanova S S Vandenheede J R JR de Witte P A PA Piette J J Agostinis P P

Oncogene 20071022 13

Photodynamic therapy (PDT) is an anticancer approach utilizing a light-absorbing molecule and visible light irradiation to generate, in the presence of O(2), cytotoxic reactive oxygen species, which cause tumor ablation. Given that the photosensitizer hypericin is under consideration for PDT treatment of bladder cancer we used oligonucleotide microarrays in the T24 bladder cancer cell line to identify differentially expressed genes with therapeutic potential. This study reveals that the expressi ...[more]

PMID: 17952126

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Dataset Information

Transcription profiling by array of human T24 bladder cancer cells in response to hypericin-mediated photodynamic therapy in the absence or presence of the p38 MAPK inhibitor PD169316

Publications

Molecular effectors and modulators of hypericin-mediated cell death in bladder cancer cells.

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