Transcription profiling of fetal lung from wild type and CREB knock-out mice

ABSTRACT: The cAMP response element binding protein (Creb) is a member of a leucine zipper transcription factor family that regulates gene expression primarily in response to the intracellular cAMP signalling pathway. Previous studies have shown Creb1-null mice suffer respiratory failure with lung atelectasis and a large reduction in Sftpd mRNA. Using a new line of Creb1-null mice we have further investigated Creb function in the developing mouse lung, focussing on differentiation of the airway epithelium. The lungs of Creb1-null fetal mice showed normal respiratory development until E17.5 when proximal and distal airways fail to inflate. Subsequent ultrastructural analysis of the lungs of E17.5 Creb1-null fetal mice revealed a defect in AEC differentiation with a reduction in proportions of type-II

ORGANISM(S): Mus musculus

SUBMITTER: Kheng Tan 

PROVIDER: E-MEXP-1295 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress