Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse E14.5 stage embryos with Myf5-Cre x DT-A ROSA knock in or Nyf5-Cre genotypes

ABSTRACT: Expression profiling of E14,5 stage Embryos of two different genotypes.

ORGANISM(S): Mus musculus

SUBMITTER: Thilo Borchardt 

PROVIDER: E-MEXP-1486 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Different autonomous myogenic cell populations revealed by ablation of Myf5-expressing cells during mouse embryogenesis.

Gensch Nicole N   Borchardt Thilo T   Schneider Andre A   Riethmacher Dieter D   Braun Thomas T  

Development (Cambridge, England) 20080326 9

The development of myogenic cells is mainly determined by expression of two myogenic factors, Myf5 and Myod1 (MyoD), which genetically compensate for each other during embryogenesis. Here, we demonstrate by conditional cell ablation in mice that Myf5 determines a distinct myogenic cell population, which also contains some Myod1-positive cells. Ablation of this lineage uncovers the presence of a second autonomous myogenic lineage, which superseded Myf5-dependent myogenic cells and expressed Myod1  ...[more]

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