Ontology highlight
ABSTRACT:
ORGANISM(S): Burkholderia ambifaria
SUBMITTER: Andrea Sass
PROVIDER: E-MEXP-2819 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Chemistry & biology 20110501 5
Gram-negative Burkholderia cepacia complex (Bcc) isolates were screened for antimicrobial activity against cystic fibrosis microbial pathogens, and the ability of B. ambifaria to inhibit B. multivorans was identified. The activity was mapped to a cluster of cryptic, quorum-sensing-regulated modular polyketide synthase (PKS) genes. Enacyloxin IIa and its stereoisomer designated iso-enacyloxin IIa were identified as metabolic products of the gene cluster, which encoded an unusual hybrid modular PK ...[more]