Transcription profiling by array of mouse epidermis and pancreas following MycERTAM activation at 4 time points
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ABSTRACT: The transcription factor Myc is a critical regulator of diverse cellular processes, including both replication and apoptosis. However, differences in Myc-regulated gene expression responsible for such opposing outcomes in vivo remain obscure. To address this we have examined time-dependent changes in global gene expression in vivo in two distinct transgenic mouse models in which conditional Myc activation promotes distinct outcomes - tissue expansion in skin suprabasal keratinocytes (SBK) or involution in pancreatic islet beta cells. We utilised the MycERTAM transgenic mouse model, allowing activation of a chimeric Myc protein via daily treatment with 4 hydroxytamoxifen (4OHT). We compared the change in expression following MycERTAM activation at 4 time points (4hrs, 8hrs, 16hrs and 32hrs following 4OHT treatment) for the two tissues to identify genes whose expression profiles differ between the two.
ORGANISM(S): Mus musculus
SUBMITTER: Sam Robson
PROVIDER: E-MEXP-2952 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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