Context-dependent actions of Exendin-4 on β-cell function and dynamic changes in islet gene expression over time in vivo

ABSTRACT: GLP-1 analogues, such as exendin-4, preserve functional β-cell mass in various model systems and are revolutionising management of type 2 diabetes. Yet, comparatively little is known about effectiveness in the face of severe β-cell depletion. Moreover, direct and sequential effects of exendin-4 on islet-specific gene expression over time in vivo are not well characterised. To address these issues and others, we have examined the time-dependent effects of exendin-4 treatment on β-cell mass regulation alongside accompanying changes in islet gene expression in vivo. Context-dependent actions were assessed by comparing effects on normal islets and also following massive toxigenetic β-cell ablation in pIns-MYCERTAM transgenic mice in vivo. Despite over 90% loss of β-cell mass, exendin-4 tr

ORGANISM(S): Mus musculus

SUBMITTER: Michael Khan 

PROVIDER: E-GEOD-37936 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress