Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Assessing the role of microRNAs in post-transcriptional control of thymocytes and peripheral lymphocytes in NOD mice

ABSTRACT: As early as one month of age, non-obese diabetic (NOD) mice feature pancreatic infiltration of autoreactive T lymphocytes, which destruct insulin-producing beta cells, leading to autoimmune diabetes mellitus (T1D) within eight months. Thus, we hypothesized that during the development of T1D, the transcriptional modulation of immune reactivity genes, as well as, modulation of microRNAs (miRNAs) may occur during thymocytes mature into peripheral CD3+ T lymphocytes. Our aim is to analyze the transcriptional modulation of mRNA and microRNAs during development of thymocytes into peripheral CD3+ T lymphocytes in the context of the emergence of T1D.

ORGANISM(S): Mus musculus

DISEASE(S): Diabetic

SUBMITTER: Geraldo Passos

PROVIDER: E-MEXP-3235 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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